139 OzcanU.YilmazE.OzcanL.FuruhashiM.VaillancourtE.SmithR
It has recently been shown that GLP-1R neurons in the dorsomedial hypothalamic nucleus regulate pancreatic activity by affecting the dorsal motor nucleus of the vagus, specifically lowering blood glucose levels by increasing insulin release (Huang et al., 2022)
Key regions of the hypothalamus in this regard include the ventromedial hypothalamus (VMH), dorsomedial hypothalamus (DMH), PVH, and the lateral hypothalamic area (LHA), which all receive projections from GLP-1-expressing NTS neurons, where deletion or blockade of GLP-1Rs increases food intake and body weight [72, 118,119,120]
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However, if systemic estrogen deficiency remains unaddressed, insulin resistance may continue to be hormonally driven
